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  • 60 Consultation

  • 30 min Review & 30 min Consultation
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Chiara Grisanzio

Country: Italy


Qualification: M.D.; University of Rome La Sapienza



Communication style

Experienced mentor, will speak slow in easy English, and has interacted with ESL researchers.


  1. Instructor profile
Chiara is an accomplished researcher and she has received 15 awards for her scholastic achievements, including many from the reputed Harvard Medical School. She is a published author and has presented her work at various conferences. She has delivered several (invited) talks and has also authored insightful review articles. Chiara conducted her research at the renowned Harvard Medical School, authored/co-authored multiple PNAS papers, and has received several awards for her research work.
Education
  • MD | 2003 | University of Rome La Sapienza, Italy
Research Experience
  • Dana Farber Cancer Institute, Harvard Medical School Boston, MA
  • Postdoctoral Fellow; Advisor: Matthew L. Freedman 2009-2012
  • Brigham and Women’s Hospital, Harvard Medical School Boston, MA
  • Postdoctoral Fellow; Advisor: Sabina Signoretti 2004-2009
Grants and Awards
  • Harvard Stem Cell Institute Seed Grant 2009
  • Harvard Medical School Research Excellence Award, Biomedical Research Institute 2009
  • Brigham and Women’s Hospital, Harvard Medical School
  • Best Poster Award, Department of Pathology Research Celebration 2009
  • Brigham and Women’s Hospital, Harvard Medical School
  • Ruth and William Silen, M.D., Poster Award 2008
  • New England Science Symposium, Harvard Medical School
  • Research Fellowship Grant Renewal 2008
  • American Italian Cancer Foundation, New York
  • Best Poster Award, Department of Pathology Research Celebration 2007
  • Brigham and Women’s Hospital, Harvard Medical School
  • Research Fellowship Grant Award 2006
  • American Italian Cancer Foundation, New York
  • Research Fellowship Award 2005 | University of Rome La Sapienza (Italy)
  • M.D., summa cum laude 2003 | University of Rome La Sapienza (Italy)
Editorial Activity
  • Reviewer for Clinical Cancer Research 2009-2012
Conference Presentations
  • Grisanzio C, Browne D, Chang M, Collins M, Signoretti S. Identification of stem cells in the prostate epithelium. Biomedical Research Institute, Brigham and Women’s Hospital, May 18, 2009.
  • Grisanzio C, Browne D, Chang M, Collins M, Signoretti S. Identification of stem cells in the prostate epithelium. Brigham and Women’s Hospital, Department of Pathology Research Celebration, May 15, 2009.
  • Grisanzio C, Seeley A, Amato A, Di Napoli A and Signoretti S. Development of Mouse Orthotopic Xenografts of Human Renal Cell Carcinoma. Brigham and Women’s Hospital, Department of Pathology Research Celebration, May 2nd 2008.
  • Grisanzio C, Seeley A, Amato A, Di Napoli A and Signoretti S. Development of Mouse Orthotopic Xenografts of Human Renal Cell Carcinoma. AACR Meeting, April 14th 2008.
  • Grisanzio C, Seeley A, Amato A, Di Napoli A and Signoretti S. Development of Mouse Orthotopic Xenografts of Human Renal Cell Carcinoma. New England Science Symposium, April 6th 2008.
  • Di Napoli A, Grisanzio C, Ghebremichael M, Seeley A, Amato AM, Atkins M, Signoretti S. CAIX Expression Correlates with VHL Mutational Status in Sporadic Clear Cell Carcinoma of the Kidney. USCAP Annual Meeting 2008.
  • Grisanzio C, Sabbisetti V, Browne D, Signoretti S. p63 in the development and maintenance of the prostate epithelium. IMPaCT Meeting, September 5-8, 2007.
  • Grisanzio C, Sabbisetti V, Browne D, Signoretti S. p63 in the development and maintenance of the prostate epithelium. Brigham and Women’s Hospital, Department of Pathology Research Celebration, May 18, 2007.
  • Beroukhim R, Pires MM, Mertz K, Grisanzio C, Linhart D, Moch H, Meyerson M, Rubin M, Sellers WR, Signoretti S. Molecular analysis of renal cell carcinoma using single nucleotide polymorphisms (SNP) arrays. DF/HCC Renal Cancer SPORE/Program Retreat, Dedham, MA, October 14, 2005.
  • Sebastiani V, Grisanzio C, Piccini V, Monaco S, Brenna A, Romagnoli F, Visca P, Alò PL. Immunohistochemical Expression of Human Erythrocyte Glucose Transporter (GLUT1) and Fatty Acid Synthase in Endometrial Carcinomas. Pathologica 2002; 94(2): 102.
  • Sebastiani V, Grisanzio C, Pallicca S, Caffo A, Moauro M, Ricci F, Botti C, Alò PL. Immunohistochemical Expression of Fatty Acid Synthase in Cytotrophoblast and Decidual Cells Pathologica 2002; 94(2): 101.
Invited Talks
  • Center for Functional Cancer Epigenetics Meeting 2011, Dana Farber Cancer Institute, Harvard Medical School Boston, MA
  • Broad Institute Cancer Meeting 2011, Massachusetts Institute of Technology Cambridge, MA
  • Kidney Cancer Program 2008, Beth Israel Deaconess Medical Center Boston, MA
  • Prostate Cancer Research Forum 2008, Toronto, Canada
  • Department of Defence 2007, IMPACT Meeting Atlanta, GA
  • Kidney Cancer Program 2007, Beth Israel Deaconess Medical Center Boston, MA
  • Department of Pathology Research in Progress Seminars 2006, Brigham and Women’s Hospital, Harvard Medical School Boston, MA
Review Articles
  • Grisanzio C, Freedman ML. Chromosome 8q24-Associated cancers and MYC. Genes Cancer. 2010 Jun; 1(6):555-9.
  • Grisanzio C, Signoretti S. p63 in prostate biology and pathology. J Cell Biochem. 2008 Apr 1; 103(5): 1354-68.
Publications
  • Pignon JC, Grisanzio C, Carvo I, Werner L, Regan M, Wilson EL, Signoretti S. Cell kinetic studies fail to identify sequentially proliferating progenitors as the major source of epithelial renewal in the adult murine prostate. PLoS One, 2015 May 29;10(5):e0128489.
  • Pignon JC, Grisanzio C, Geng Y, Song J, Shivdasani RA, Signoretti S. p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. PNAS, 2013 May 14;110(20):8105-10.
  • Grisanzio C, Werner L, Takeda D, Awoyemi BC, Pomerantz MM,, Yamada H, Sooriakumaran P, Robinson B, Leung R, Schinzel AC, Mills I, Ross-Adams H, Neal DE, Kido M, Yamamoto T, Petrozziello G, Stack E, Lis R, Kantoff PW, Loda M, Sartor OA, Egawa S, Tewari AK, Hahn WC, Freedman ML. Genetic and Functional Analyses Implicate NUDT11, HNF1B, and SLC22A3 in prostate cancer pathogenesis. PNAS, 2012 Jul 10;109(28):11252-7.
  • Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. PNAS 2011 Aug 16;108(33):13379-86.
  • Grisanzio C, Seeley A, Chang M, Collins M, Di Napoli A, Percy A, Berouhim R, Signoretti S. Development Of Clinically Relevant Orthotopic Models Of Human Renal Cell Carcinoma. J Pathol. 2011 Oct; 225(2):212-21.
  • Genega EM, Ghebremichael M, Najarian R, Fu Y, Wang Y, Argani P, Grisanzio C, Signoretti S. Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade Am J Clin Pathol. 2010 Dec; 134(6): 873-9.
  • Ahmadiyeh N, Pomerantz MM, Grisanzio C, Herman P, Jia L, Almendro V, He HH, Brown M, Liu XS, Davis M, Caswell JL, Beckwith CA, Hills A, Macconaill L, Coetzee GA, Regan MM, Freedman ML. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. PNAS, 2010 May 7 [Epub ahead of print].
  • Migita T, Ruiz S, Fornari A, Inazuka F, Fiorentino M, Zadra G, Grisanzio C, Palescandolo E, Priolo C, Shin E, Fiore C, Xie W, Kung AL, Febbo PG, Subramanian A, Mucci L, Ma J, Signoretti S, Stampfer M, Hahn WC, Finn S, Loda M. Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer. J Natl Cancer Inst. 2009 Mar 24 [Epub ahead of print].
  • Majumder P, Grisanzio C, O’Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, Fedele G, Baek W, Wang S, Ellwood-Yen K, Wu H, Sawyers CL, Signoretti S, Hahn WC, Loda M, Sellers WR. A prostatic intraepithelial neoplasia-dependent p27kip1 checkpoint induces senescence, inhibits cell proliferation and cancer progression. Cancer Cell. 2008 Aug 12; 14(2): 146-55.
  • Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG Jr. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol. 2008 Mar; 10(3): 361-9.
  • Signoretti S, Pires MM, Lindauer M, Horner JW, Grisanzio C, Dhar S, Majumder P, McKeon F, Kantoff PW, Sellers WR, Loda M. p63 regulates commitment to the prostate cell lineage. Proc Natl Acad Sci U S A. 2005 Aug 9; 102 (32): 11355-60. Epub 2005 Jul 28.
Books
  • Grisanzio C. and Signoretti S, “Adult Prostate Epithelium Renewal, Stem Cells and Cancer” chapter of book “Stem Cells and Cancer”, 2009, Humana Press.
Licensure and Certification
  • State Licensure Examination 2004 Certificate of Enrolment in the Register of Doctors-Surgeons (Licence #53221) Rome, Italy.

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